Opportunity Information: Apply for RFA HL 17 024
The Revision Applications for Regenerative Medicine Innovation Projects (RMIP) (R41/R42) opportunity, announced by the National Institutes of Health (NIH) in collaboration with participating NIH Institutes and Centers and the U.S. Food and Drug Administration (FDA), is designed specifically for small businesses that already hold an active STTR award under the R41 or R42 mechanism. Instead of funding entirely new standalone projects, this announcement focuses on “competing revisions,” meaning applicants are requesting additional funds during a current budget period to expand the approved scope of an existing STTR project or to broaden or modify the approved research protocol. The intent is to accelerate progress on ongoing small business-led translational efforts by enabling a larger or more clinically oriented push than the original award budget or scope allowed.
The scientific and development focus is regenerative medicine that uses adult stem cells, with a clear emphasis on clinical research studies that can move the field toward safe, effective, and ultimately approvable therapies. Projects are expected to be innovative and to directly address well-recognized bottlenecks that commonly slow or complicate regenerative medicine development. Rather than supporting basic discovery work, the program leans toward practical, solution-oriented efforts that improve the pathway from development to evaluation and, eventually, clinical use. A central theme is helping applicants tackle problems that are broadly relevant across regenerative medicine products and that, if solved, would strengthen the quality of evidence and confidence around these technologies.
A major priority in the announcement is product development work that aligns with regulatory expectations and supports regulatory submissions. In practice, that means the proposed expansion should meaningfully improve the readiness of the product or the supporting data package in areas regulators commonly scrutinize. The FOA highlights needs such as better tools, methods, standards, or other forms of applied science that improve understanding and assessment of manufacturing and product performance. Examples of the kinds of issues this could cover include improving manufacturing consistency, developing or validating quality control assays, strengthening approaches to safety testing, and generating more reliable measures of effectiveness or potency. Overall, the program is aiming for advancements that make regenerative medicine products easier to manufacture reproducibly, evaluate rigorously, and justify scientifically in a regulatory context.
Eligibility is narrow and clearly limited to U.S.-based small businesses, consistent with the STTR framework and the revision-only nature of the funding. Foreign institutions are not eligible to apply, and non-U.S. components of U.S. organizations are also not eligible. In addition, foreign components as defined by the NIH Grants Policy Statement are not allowed, reinforcing that all supported work under this revision must remain within allowable domestic organizational arrangements. The opportunity is categorized as a discretionary grant within the health-related funding activity space and is tied to Funding Opportunity Number RFA-HL-17-024, with an original closing date of June 26, 2017, and a creation date of April 28, 2017. The eligible applicant type is explicitly small businesses, reflecting the program’s goal of advancing commercially relevant regenerative medicine development through industry-academic collaboration typical of STTR awards.Apply for RFA HL 17 024
- The National Institutes of Health in the food and nutrition, health sector is offering a public funding opportunity titled "Revision Applications for Regenerative Medicine Innovation Projects (RMIP) (R41/R42)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121, 93.173, 93.233, 93.242, 93.286, 93.350, 93.837, 93.838, 93.839, 93.840, 93.846, 93.847, 93.853, 93.855, 93.856, 93.866, 93.867.
- This funding opportunity was created on 2017-04-28.
- Applicants must submit their applications by 2017-06-26. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Small businesses.
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Applicants also applied for:
Applicants who have applied for this opportunity (RFA HL 17 024) also looked into and applied for these:
| Funding Opportunity |
|---|
| Revision Applications for Regenerative Medicine Innovation Projects (RMIP) (UC4) Apply for RFA HL 17 027 Funding Number: RFA HL 17 027 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| NIDDK Central Repositories Non-renewable Sample Access (X01) Apply for PAR 17 270 Funding Number: PAR 17 270 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Therapeutic Strategies for the Converging TB/T2DM/HIV Epidemics (R01) Apply for PA 17 283 Funding Number: PA 17 283 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Administrative Supplements for Participation in the Concept to Clinic: Commercializing Innovation (C3i) Program (Admin Supp) Apply for PA 17 286 Funding Number: PA 17 286 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Psychological, Behavioral, and Neurocognitive-Focused Ancillary Studies to the Molecular Transducers of Physical Activity in Humans Consortium (MoTrPAC) (U01) Apply for RFA DK 17 009 Funding Number: RFA DK 17 009 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $3,000,000 |
| Center for Identification and Study of Individuals with Atypical Diabetes Mellitus (U54) Apply for RFA DK 17 006 Funding Number: RFA DK 17 006 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Limited Competition for the Continuation of the Chronic Renal Insufficiency Cohort Scientific and Data Coordinating Center (U24) Apply for RFA DK 17 506 Funding Number: RFA DK 17 506 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $2,250,000 |
| Limited Competition for the Continuation of the Chronic Renal Insufficiency Cohort (CRIC) Clinical Centers (U01) Apply for RFA DK 17 505 Funding Number: RFA DK 17 505 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $650,000 |
| Developmental Centers for Interdisciplinary Research in Benign Urology (P20 - Clinical Trials Not Allowed) Apply for RFA DK 17 033 Funding Number: RFA DK 17 033 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $200,000 |
| Investigator-Initiated Clinical Trials Targeting Diseases within the Mission of NIDDK (R01-Clinical Trial Required) Apply for PA 18 330 Funding Number: PA 18 330 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| NIDDK Program Projects (P01 Clinical Trial Optional) Apply for PAR 18 012 Funding Number: PAR 18 012 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $6,250,000 |
| Ancillary Studies to Major Ongoing Clinical Research Studies to Advance Areas of Scientific Interest within the Mission of the NIDDK (R01 Clinical Trial Optional) Apply for PAR 18 042 Funding Number: PAR 18 042 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Metabolic Contributions to the Neurocognitive Complications of Diabetes: Ancillary Studies (R01 Clinical Trial Optional) Apply for PAR 18 051 Funding Number: PAR 18 051 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Secondary Analyses in Obesity, Diabetes and Digestive and Kidney Diseases (R21 Clinical Trial Optional) Apply for PA 18 052 Funding Number: PA 18 052 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $200,000 |
| Pilot and Feasibility Clinical Research Grants in Kidney Diseases (R21 Clinical Trial Optional) Apply for PAR 18 100 Funding Number: PAR 18 100 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $200,000 |
| Pilot and Feasibility Clinical and Translational Research Studies in Digestive Diseases and Nutrition (R21 Clinical Trial Optional) Apply for PA 18 099 Funding Number: PA 18 099 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $200,000 |
| Pilot and Feasibility Clinical Research Grants in Urologic Disorders (R21 Clinical Trial Optional) Apply for PAR 18 101 Funding Number: PAR 18 101 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $200,000 |
| Small Grants for New Investigators to Promote Diversity in Health-Related Research (R21 Clinical Trial Optional) Apply for PAR 18 102 Funding Number: PAR 18 102 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $125,000 |
| Limited Competition: Small Grant Program for NIDDK K01/K08/K23 Recipients (R03 Clinical Trial Optional) Apply for PAR 18 103 Funding Number: PAR 18 103 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $50,000 |
| Addressing Health Disparities in NIDDK Diseases (R01 - Clinical Trial Not Allowed) Apply for PA 18 412 Funding Number: PA 18 412 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
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