Opportunity Information: Apply for RFA RM 15 014
The Molecular Transducers of Physical Activity Consortium Coordinating Center (CCC) (U24) opportunity (RFA-RM-15-014) is a National Institutes of Health (NIH) cooperative agreement designed to support a single Coordinating Center for the Molecular Transducers of Physical Activity Consortium (MoTrPAC). MoTrPAC is a Common Fund effort focused on understanding the molecular changes in the body that are triggered by physical activity. Rather than funding another individual research project site, this award is meant to fund the central hub that keeps a large, multi-site consortium operating as one cohesive program, with consistent protocols, shared standards, and coordinated outputs.
The core purpose of the CCC is overall coordination and day-to-day operational management of the MoTrPAC consortium. That includes organizing and supporting consortium governance, communication, and planning across participating institutions and study teams. A major responsibility is managing the development, harmonization, and implementation of study protocols, so that data and biospecimens collected across sites are comparable and can be analyzed together. The CCC is also expected to coordinate logistics for the collection, management, and distribution of both data and biological samples generated during the project. In practical terms, this typically means overseeing standardized operating procedures, timelines, data flow, quality control processes, and systems that ensure materials and datasets move to the right places securely and efficiently.
Another major deliverable is helping create a lasting research resource for future investigators. This implies building the infrastructure and processes needed for long-term usability of consortium outputs, such as well-annotated datasets, curated metadata, and responsibly managed biospecimen inventories, along with clear rules for access and sharing. The intent is not just to run the studies while the award is active, but to ensure that what the consortium produces can be reused later by the broader scientific community, consistent with NIH policies and the NIH Grants Policy Statement.
This funding opportunity is categorized as discretionary funding, using a cooperative agreement mechanism (U24). A cooperative agreement means NIH is expected to have substantial involvement in the project, so the CCC will operate in close partnership with NIH program leadership and the rest of the consortium. The activity category is health, and the associated CFDA number is 93.310. NIH anticipated making one award under this announcement, emphasizing that the CCC is intended to be a single central coordinating entity rather than multiple competing centers. The announcement was created on October 8, 2015, with an original closing date of March 18, 2016. The award ceiling is not specified in the provided source.
Eligibility is broad across many U.S.-based organization types. Eligible applicants include various levels of government (state, county, city or township, special district), independent school districts, public and state-controlled institutions of higher education, private institutions of higher education, federally recognized Native American tribal governments, and Native American tribal organizations that are not federally recognized tribal governments. Both nonprofit organizations (with or without 501(c)(3) status) and for-profit organizations (other than small businesses), as well as small businesses, may apply. The opportunity also explicitly highlights additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, Indian/Native American tribal governments other than federally recognized, and U.S. territories or possessions.
Foreign participation is limited. Non-domestic (non-U.S.) entities are not eligible to apply as applicants, and non-domestic components of U.S. organizations are not eligible to apply. However, foreign components as defined in the NIH Grants Policy Statement are allowed, meaning certain discrete parts of the work can be performed outside the U.S. under the rules NIH sets for foreign components, even though the applicant organization itself must be domestic and the overall award remains U.S.-based.
In short, this FOA supports the central coordinating infrastructure for MoTrPAC, with responsibilities spanning consortium-wide coordination, protocol and operations management, data and biospecimen logistics, and building a durable scientific resource that extends the impact of the consortium beyond the funded project period.Apply for RFA RM 15 014
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Molecular Transducers of Physical Activity Consortium Coordinating Center (CCC) (U24)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310.
- This funding opportunity was created on 2015-10-08.
- Applicants must submit their applications by 2016-03-18. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the name and number of this funding opportunity?
This opportunity is the Molecular Transducers of Physical Activity Consortium Coordinating Center (CCC) (U24), RFA-RM-15-014.
Which agency is offering this opportunity?
The opportunity is offered by the National Institutes of Health (NIH).
What is MoTrPAC?
MoTrPAC (the Molecular Transducers of Physical Activity Consortium) is an NIH Common Fund effort focused on understanding the molecular changes in the body that are triggered by physical activity.
What is the overall purpose of the Coordinating Center (CCC)?
The CCC is intended to serve as the central hub for MoTrPAC, providing overall coordination and day-to-day operational management so the consortium functions as one cohesive, multi-site program.
Is this award meant to fund a research project site?
No. This award is specifically meant to fund the central coordinating infrastructure rather than an additional individual research project site.
How many awards does NIH anticipate making under this announcement?
NIH anticipated making one award under this announcement, reflecting the goal of supporting a single, central coordinating entity.
What funding mechanism is used for this opportunity?
This opportunity uses a cooperative agreement mechanism (U24).
What does a cooperative agreement (U24) imply for how the project will be run?
A cooperative agreement means NIH is expected to have substantial involvement in the project. The CCC would operate in close partnership with NIH program leadership and the rest of the consortium.
What types of activities is the CCC expected to coordinate?
The CCC is expected to coordinate consortium governance, communication, and planning across participating institutions and study teams, along with the operational processes needed to keep the consortium running smoothly day to day.
What is the CCC's role in study protocols?
A major responsibility is managing the development, harmonization, and implementation of study protocols so that data and biospecimens collected across multiple sites are comparable and can be analyzed together.
What kinds of operational elements might the CCC oversee?
In practical terms, the CCC typically oversees standardized operating procedures, timelines, data flow, quality control processes, and systems that ensure materials and datasets move to the right places securely and efficiently.
What is the CCC expected to do regarding data?
The CCC is expected to coordinate logistics for the collection, management, and distribution of data generated during the project, including processes that support consistent standards and coordinated outputs across sites.
What is the CCC expected to do regarding biospecimens?
The CCC is expected to coordinate logistics for the collection, management, and distribution of biological samples generated during the project, supporting consistent handling and comparability across sites.
Does this opportunity emphasize creating resources for future researchers?
Yes. A major deliverable is helping create a lasting research resource for future investigators, including infrastructure and processes for long-term usability of consortium outputs.
What does "lasting research resource" mean in this context?
It implies building infrastructure and processes that support long-term reuse of consortium outputs, such as well-annotated datasets, curated metadata, and responsibly managed biospecimen inventories, along with clear rules for access and sharing.
Is the goal only to run studies during the award period?
No. The intent includes ensuring that what the consortium produces can be reused later by the broader scientific community, consistent with NIH policies and the NIH Grants Policy Statement.
What is the activity category for this opportunity?
The activity category is health.
What is the CFDA number associated with this opportunity?
The associated CFDA number is 93.310.
What kind of funding is this described as?
This funding opportunity is categorized as discretionary funding.
When was the announcement created?
The announcement was created on October 8, 2015.
What was the original closing date?
The original closing date was March 18, 2016.
Is the award ceiling specified?
No. The award ceiling is not specified in the provided information.
Who is eligible to apply?
Eligibility is broad across many U.S.-based organization types, including government entities, schools and higher education institutions, tribal governments and organizations, nonprofits, for-profits (other than small businesses), and small businesses, along with several specifically highlighted institution and organization categories.
Are state and local government entities eligible?
Yes. Eligible applicants include state governments, county governments, city or township governments, and special district governments.
Are educational institutions eligible?
Yes. Eligible applicants include independent school districts, public and state-controlled institutions of higher education, and private institutions of higher education.
Are nonprofit organizations eligible?
Yes. Both nonprofit organizations with 501(c)(3) status and nonprofit organizations without 501(c)(3) status are eligible.
Are for-profit organizations eligible?
Yes. For-profit organizations (other than small businesses) are eligible, and small businesses are also eligible.
Are tribal entities eligible?
Yes. Eligible applicants include federally recognized Native American tribal governments and Native American tribal organizations that are not federally recognized tribal governments. The opportunity also highlights Indian/Native American tribal governments other than federally recognized.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are explicitly highlighted among eligible applicant categories.
Are certain minority-serving institutions specifically highlighted as eligible?
Yes. The opportunity explicitly highlights Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, Hispanic-serving Institutions, HBCUs, and TCCUs.
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are explicitly highlighted among eligible applicant categories.
Are eligible federal agencies included?
Yes. Eligible federal agencies are explicitly highlighted among eligible applicant categories.
Can non-U.S. (foreign) organizations apply as the applicant?
No. Non-domestic (non-U.S.) entities are not eligible to apply as applicants.
Can a non-domestic component of a U.S. organization apply?
No. Non-domestic components of U.S. organizations are not eligible to apply.
Are any foreign activities allowed at all?
Yes. Foreign components (as defined in the NIH Grants Policy Statement) are allowed, meaning discrete parts of the work may be performed outside the U.S. under NIH rules, as long as the applicant organization is domestic and the overall award remains U.S.-based.
What are "coordinated outputs" and "shared standards" in this program?
In this context, they refer to consortium-wide alignment on protocols, standards, and operational processes so that multiple sites produce consistent, comparable data and biospecimens that can be combined and used together.
What is the CCC's role in governance and communications?
The CCC is responsible for organizing and supporting consortium governance, communication, and planning across participating institutions and study teams.
What is meant by "harmonization" of protocols?
It means aligning and standardizing protocols across sites so that methods are consistent and results (including data and biospecimens) are comparable across the consortium.
What is the main takeaway for potential applicants?
The opportunity is designed to support a single, centralized coordinating center that manages consortium operations, protocol harmonization, and data/biospecimen logistics while helping ensure MoTrPAC outputs become a durable research resource consistent with NIH policies.
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