Opportunity Information: Apply for PAR 21 227
The National Institutes of Health (NIH) released this discretionary funding opportunity, PAR-21-227, to establish a Resource Center that supports the Support for Research Excellence (SuRE) Program. The overall aim is to help develop and sustain research excellence at U.S. colleges and universities that historically receive limited NIH research funding and that educate and train substantial numbers of students from groups underrepresented in biomedical research (as referenced in NIH Notice NOT-OD-20-031). The mechanism is a U24 cooperative agreement, which generally means NIH expects substantial involvement with the awardee in shaping, coordinating, and overseeing activities to ensure the Resource Center meets program-wide goals. Clinical trials are not allowed under this opportunity.
At a practical level, this Resource Center is intended to function as a centralized hub that strengthens the SuRE initiative across participating institutions. Rather than directly funding individual research projects the way many research grants do, a U24 Resource Center typically focuses on coordinated services, infrastructure, technical assistance, training, and program support that raise the quality and competitiveness of research environments. In the SuRE context, the Resource Center would be expected to help institutions build sustainable capacity for biomedical research and mentoring, improve the research ecosystem and support structures, and ultimately enhance the ability of investigators and trainees at these institutions to succeed in NIH-relevant research careers. The emphasis on institutions with limited NIH support signals a capacity-building focus, particularly for campuses that may have fewer established research resources, smaller administrative research offices, or less access to mentorship networks and grant development support.
Eligibility is broad across U.S.-based organizations, spanning multiple levels of government (state, county, city/township, and special districts), independent school districts, public and state-controlled institutions of higher education, private institutions of higher education, federally recognized Native American tribal governments, and Native American tribal organizations that are not federally recognized. The opportunity also allows nonprofit organizations with or without 501(c)(3) status (when they are not institutions of higher education), for-profit organizations (other than small businesses), and small businesses, as well as other organizations that meet NIH requirements. The announcement explicitly highlights categories of institutions and organizations that align closely with the SuRE mission, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs). It also notes eligible federal agencies, faith-based or community-based organizations, regional organizations, and U.S. territories or possessions as eligible applicants, reflecting NIH interest in reaching a wide range of U.S. settings where underrepresented students are educated and trained.
There are important geographic and foreign involvement restrictions. Non-U.S. entities (foreign institutions) are not eligible to apply, non-domestic components of U.S. organizations are not eligible, and foreign components (as defined by the NIH Grants Policy Statement) are not allowed. In other words, this Resource Center must be fully U.S.-based without foreign components embedded in the work.
From a funding perspective, the listed award ceiling is $750,000, which indicates the maximum amount NIH expects to provide per award (typically per year, depending on NIH’s specific budget structure for the FOA, though the ceiling is presented here as a single figure). The activity category is Health, and the CFDA/Assistance Listing number is 93.859. The original closing date shown is September 24, 2021, and the announcement was created on April 27, 2021. While the posted date and deadline indicate this particular cycle is historical, the details still describe the structure and intent of the SuRE Resource Center concept and the kinds of applicants NIH aimed to engage.
In summary, PAR-21-227 is a cooperative agreement opportunity to create a national or program-level Resource Center that helps institutions with limited NIH funding build durable biomedical research capacity and support researchers and trainees from underrepresented groups. It is designed to provide coordinated, non-clinical-trial support functions that improve research excellence and long-term sustainability at eligible U.S. higher education institutions and partnering organizations, with explicit exclusions for foreign applicants and any foreign components.Apply for PAR 21 227
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Resource Center for the Support for Research Excellence (SuRE) Program (U24 - Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.859.
- This funding opportunity was created on 2021-04-27.
- Applicants must submit their applications by 2021-09-24. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $750,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: NIH PAR-21-227 (SuRE Program Resource Center)
What is PAR-21-227?
PAR-21-227 is a discretionary funding opportunity released by the National Institutes of Health (NIH) to establish a Resource Center that supports the Support for Research Excellence (SuRE) Program.
What is the main goal of this funding opportunity?
The overall aim is to help develop and sustain research excellence at U.S. colleges and universities that historically receive limited NIH research funding and that educate and train substantial numbers of students from groups underrepresented in biomedical research (as referenced in NIH Notice NOT-OD-20-031).
What type of award mechanism is used for this opportunity?
This opportunity uses a U24 cooperative agreement mechanism.
What does a U24 cooperative agreement imply about NIH involvement?
A U24 cooperative agreement generally means NIH expects substantial involvement with the awardee in shaping, coordinating, and overseeing activities to ensure the Resource Center meets program-wide goals.
Are clinical trials allowed under PAR-21-227?
No. Clinical trials are not allowed under this opportunity.
What is the Resource Center expected to do in practical terms?
The Resource Center is intended to function as a centralized hub that strengthens the SuRE initiative across participating institutions by providing coordinated support functions (rather than funding individual research projects directly).
Does this opportunity fund individual research projects like a typical research grant?
No. The Resource Center concept described here is focused on coordinated services, infrastructure, technical assistance, training, and program support, rather than directly funding individual research projects.
What kinds of activities are typical for a U24 Resource Center in the SuRE context?
Based on the description provided, the Resource Center would typically focus on coordinated services and supports that raise the quality and competitiveness of research environments, including infrastructure and program support, technical assistance, training, and other centralized functions that strengthen the SuRE initiative across institutions.
Who is the Resource Center meant to support?
It is meant to support U.S. colleges and universities that historically receive limited NIH research funding and that educate and train substantial numbers of students from underrepresented groups in biomedical research.
What outcomes is the Resource Center intended to promote?
The Resource Center is intended to help institutions build sustainable capacity for biomedical research and mentoring, improve the research ecosystem and support structures, and enhance the ability of investigators and trainees at these institutions to succeed in NIH-relevant research careers.
What does NIH mean by emphasizing institutions with limited NIH support?
The emphasis signals a capacity-building focus, particularly for campuses that may have fewer established research resources, smaller administrative research offices, or less access to mentorship networks and grant development support.
Who is eligible to apply?
Eligibility is broad across U.S.-based organizations, including multiple levels of government (state, county, city/township, and special districts), independent school districts, public and state-controlled institutions of higher education, private institutions of higher education, federally recognized Native American tribal governments, and Native American tribal organizations that are not federally recognized.
Are nonprofit organizations eligible?
Yes. Nonprofit organizations with or without 501(c)(3) status are eligible when they are not institutions of higher education.
Are for-profit organizations eligible?
Yes. For-profit organizations (other than small businesses) are eligible, and small businesses are also listed as eligible applicants.
Are federal agencies eligible to apply?
Yes. Eligible federal agencies are explicitly noted as eligible applicants.
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are explicitly noted as eligible applicants.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are included among eligible applicants.
Does the announcement highlight specific institution types that align with the SuRE mission?
Yes. The announcement explicitly highlights institution categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs).
Are non-U.S. (foreign) institutions eligible to apply?
No. Non-U.S. entities (foreign institutions) are not eligible to apply.
Can a U.S. organization include a non-domestic component in the application?
No. Non-domestic components of U.S. organizations are not eligible.
Are foreign components allowed in any form?
No. Foreign components (as defined by the NIH Grants Policy Statement) are not allowed.
Does the Resource Center need to be fully U.S.-based?
Yes. The opportunity states that the Resource Center must be fully U.S.-based without foreign components embedded in the work.
What is the maximum funding amount listed for an award?
The listed award ceiling is $750,000.
What does the award ceiling represent?
It indicates the maximum amount NIH expects to provide per award. The ceiling is presented as a single figure in the information provided.
What is the activity category for this opportunity?
The activity category is Health.
What is the CFDA/Assistance Listing number for this opportunity?
The CFDA/Assistance Listing number is 93.859.
When was this funding opportunity created, and what was the closing date shown?
The announcement was created on April 27, 2021, and the original closing date shown is September 24, 2021.
Is this opportunity still open based on the dates provided?
Based on the posted closing date of September 24, 2021, the cycle described appears to be historical.
How is this opportunity best summarized?
PAR-21-227 is a cooperative agreement opportunity to create a Resource Center that strengthens the SuRE Program by providing coordinated, non-clinical-trial support to help eligible U.S. institutions with limited NIH funding build durable biomedical research capacity and support researchers and trainees from underrepresented groups, with explicit exclusions for foreign applicants and any foreign components.
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