Opportunity Information: Apply for 23 585
The National Science Foundation (NSF) BioFoundries program (Funding Opportunity Number 23-585) is a large-scale infrastructure grant opportunity aimed at building and operating advanced facilities that can accelerate progress in modern biology and biotechnology. The central idea is that many of today s biggest scientific and societal questions in areas like biological sciences, chemical biology, biotechnology, and bioengineering require tools and capabilities that are too complex, expensive, and multidisciplinary to sit inside a single investigator s lab. NSF is looking to fund BioFoundries that provide broad, reliable access to cutting-edge instrumentation, automated workflow pipelines, sophisticated computing and data systems, and specialized expertise so researchers can design, build, test, and scale biological systems and technologies more efficiently and reproducibly.
A BioFoundry, as described in this opportunity, is meant to function as an integrated scientific ecosystem rather than a standalone core facility. NSF emphasizes tight integration across intellectual, technical, digital, and physical infrastructure so that technology development, foundational interdisciplinary research, and workforce training reinforce each other. These facilities are expected to serve as access points where new biological technologies, standardized and automated processes, software tools, and knowledgebases are developed, refined, and shared. Importantly, they should support both in-house research programs (conducted by BioFoundry staff scientists and engineers) and external user-initiated projects, allowing outside researchers to take full advantage of the latest methods and automation. The program also highlights the need for BioFoundries to be capable of bespoke design and process scale-up in response to user needs, which ties directly to translating discoveries into practical applications for the bioeconomy and broader national and societal priorities.
NSF places strong weight on reproducibility and knowledge sharing. BioFoundries are expected to improve the reliability of life science results by promoting standardized workflows, automation, better experimental tracking, and stronger data and knowledge sharing practices. The solicitation envisions communities of practitioners who share tools, reagents, workflows, software, samples, and data, with knowledge exchange treated as a core operating principle rather than an add-on. This shared infrastructure and culture is meant to strengthen collaborations, enable researchers to work in new ways, and create new models for research and education and training that speed up discovery and development.
In terms of structure, NSF explicitly encourages applicants to draw on lessons from existing national and international biofoundries and to consider different organizational models. Proposals may be centralized (a single major facility), distributed (capabilities spread across sites), or consortium-based (multiple institutions operating as a coordinated network). Regardless of the model, each BioFoundry is expected to include a multidisciplinary mix of NSF-supported in-house research scientists, technical staff, and cyberinfrastructure experts, alongside external users and other contributors, all connected through shared platforms and practices.
The opportunity also builds in expectations around responsible and inclusive science. NSF notes the importance of safe, ethical, and equitable access to both knowledge and resulting products, and it calls for BioFoundries to promote diversity, equity, inclusion, and accessibility in their internal programs and external user programs. Beyond discovery, BioFoundries are also expected to help create pathways to translation, meaning they should actively support moving methods, technologies, and insights into broader use in ways that benefit society.
Administratively, this is a discretionary NSF grant opportunity in the Science and Technology and other Research and Development category. The program anticipated up to about four awards, with an award ceiling of $24,000,000 per award. The original closing date listed for this specific opportunity was October 2, 2023, and the opportunity was created May 6, 2023. Eligible applicants are listed broadly as Others, with additional eligibility details referenced in the full solicitation. The CFDA numbers span multiple NSF directorates and programs (47.041, 47.049, 47.050, 47.070, 47.074, 47.075, 47.076, 47.079, 47.083, 47.084), reflecting the cross-cutting, interdisciplinary nature of BioFoundries and the expectation that they will serve a wide range of biological and bioengineering research communities.Apply for 23 585
- The National Science Foundation in the science and technology and other research and development sector is offering a public funding opportunity titled "BioFoundries to Enable Access to Infrastructure and Resources for Advancing Modern Biology and Biotechnology" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 47.041, 47.049, 47.050, 47.070, 47.074, 47.075, 47.076, 47.079, 47.083, 47.084.
- This funding opportunity was created on May 06, 2023.
- Applicants must submit their applications by Oct 02, 2023. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $24,000,000.00 in funding.
- The number of recipients for this funding is limited to 4 candidate(s).
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
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